School of Chemical Engineering

Crystallization and Particle T echnology
Systems Engineering

Kensaku Matsunami
Postdoctoral Research Associate
Email: kmatsun@purdue.edu
Office: FRNY 2022, Purdue University, West Lafayette, IN 47906


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Experience

  • Postdoctoral Research Associate, Pharmaceutical Engineering Research Group, Ghent University
  • Post Doctoral Research Associate, The University of Tokyo

Awards and Honors

Awards

  • "Processes 2021 Best Ph.D. Thesis Award," Multidisciplinary Digital Publishing Institute (MDPI), February 2022
  • "GSDM Student Leadership Award AY2020", Global Leader Program for Social Design and Management (GSDM), March 2021
  • "Dean of the School of Engineering Award", The University of Tokyo, March 2021
  • "Young Investigator Researcher Award of the Division of SIS", Society of Chemical Engineering of Japan, November 2020
  • "GSDM Student Effort Award AY2019", Global Leader Program for Social Design and Management (GSDM), March 2020
  • Kensaku Matsunami, Shuichi Tanabe, Keita Yaginuma, Hirokazu Sugiyama, "Technical Achievement Award of the Division of SIS", Society of Chemical Engineering of Japan, April 2019
  • "Dean of the School of Engineering Award", The University of Tokyo, March 2018
  • "Best presentation award in Department of Chemical System Engineering", The University of Tokyo, March 2018
  • "Student award", SCEJ 83rd Annual Meeting, March 2018
  • "Student award", SCEJ 81st Annual Meeting, March 2016

Grants

  • "Development of design framework for solid drug product manufacturing processes" JSPS Grant-in-Aid for JSPS Fellows (DC1) JP18J22793 (FY2018–2020, JPY2,200,000)
  • "Economic evaluation of continuous solid drug product manufacturing considering material properties" Research Abroad Grant Award, The New Pharmaceutical Technology and Engineering Foundation (2019, JPY500,000)
  • Study Abroad Musha Shugyo Program, Graduate School of Engineering, The University of Tokyo (2016, JPY400,000)

Publications

  • Keita Yaginuma, Kensaku Matsunami, Laure Descamps, Alexander Ryckaert, Thomas De Beer. "Hybrid modeling of T-shaped partial least squares regression and transfer learning for formulation and manufacturing process development of new drug products." International Journal of Pharmaceutics (2024): 124463.
  • Mohamed Rami Gaddem, Junu Kim, Kensaku Matsunami, Yusuke Hayashi, Sara Badr, Hirokazu Sugiyama. "Roles of mechanistic, data-driven, and hybrid modeling approaches for pharmaceutical process design and operation." Current Opinion in Chemical Engineering 44 (2024): 101019.
  • Junu Kim, Kensaku Matsunami, Yusuke Ichida, Kozue Okamura, Sara Badr, Hirokazu Sugiyama. "Scenario Analysis of Vaccine Supply for COVID-19 in Japan Using Mathematical Models of Infectious Diseases." Journal of Chemical Engineering of Japan 57.1 (2024): 2313318.
  • Michiel Peeters, Ana Alejandra Barrera Jiménez,Kensaku Matsunami , Michael Ghijs, Eduardo Dos Santos Schultz, Mina Roudgar, Tamas Vigh, Fanny Stauffer, Ingmar Nopens, Thomas De Beer. "Analysis of the effect of formulation properties and process parameters on granule formation in twin-screw wet granulation." International Journal of Pharmaceutics 650 (2024): 123671.
  • Kensaku Matsunami, Jonathan Meyer, Martin Rowland, Neil Dawson, Thomas De Beer, Daan Van Hauwermeiren. "T-shaped partial least squares for high-dosed new active pharmaceutical ingredients in continuous twin-screw wet granulation: Granule size prediction with limited material information." International Journal of Pharmaceutics 646 (2023): 123481.
  • Kensaku Matsunami*, Tuur Vandeputte*, Ana Alejandra Barrera Jiménez, Michiel Peeters, Michael Ghijs, Daan Van Hauwermeiren, Fanny Stauffer, Eduardo dos Santos Schultz, Ingmar Nopens, Thomas De Beer. (*shared first authorship) "Validation of model-based design of experiments for continuous wet granulation and drying." International Journal of Pharmaceutics 646 (2023): 123493.
  • Yusuke Hayashi, Saho Okazaki, Kensaku Matsunami, Kazuya Tanabe, Takuya Nagato, Hirokazu Sugiyama. "Development of concentration prediction models for personalized tablet manufacturing using near-infrared spectroscopy." Chemical Engineering Research and Design 199 (2023): 507-514.
  • Michiel Peeters, Ana Alejandra Barrera Jiménez, Kensaku Matsunami, Daan Van Hauwermeiren, Fanny Stauffer, Lærke Arnfast, Tamas Vigh, Ingmar Nopens, Thomas De Beer. "Exploring the effect of raw material properties on continuous twin-screw wet granulation manufacturability." International Journal of Pharmaceutics 645 (2023): 123391.
  • Ana Alejandra Barrera Jiménez*, Kensaku Matsunami*, Daan Van Hauwermeiren, Michiel Peeters, Fanny Stauffer, Eduardo dos Santos Schultz, Ashish Kumar, Thomas De Beer, Ingmar Nopens. (*shared first authorship) "Partial least squares regression to calculate population balance model parameters from material properties in continuous twin-screw wet granulation." International Journal of Pharmaceutics 640 (2023): 123040.
  • Michiel Peeters, Ana Alejandra Barrera Jiménez, Kensaku Matsunami, Fanny Stauffer, Ingmar Nopens, Thomas De Beer. "Evaluation of the influence of material properties and process parameters on granule porosity in twin-screw wet granulation." International Journal of Pharmaceutics 641 (2023): 123010.
  • Ana Alejandra Barrera Jiménez*, Kensaku Matsunami*, Daan Van Hauwermeiren, Michiel Peeters, Fanny Stauffer, Eduardo dos Santos Schultz, Ashish Kumar, Thomas De Beer, Ingmar Nopens. (*shared first authorship) "Linking material properties to 1D-PBM parameters towards a generic model for twin-screw wet granulation." Chemical Engineering Research and Design 193 (2023): 713-724.
  • Ana Alejandra Barrera Jiménez*, Kensaku Matsunami*, Michael Ghijs, Daan Van Hauwermeiren, Michiel Peeters, Fanny Stauffer, Thomas De Beer, Ingmar Nopens. (*shared first authorship) "Model development and calibration of two-dimensional population balance model for twin-screw wet granulation based on particle size distribution and porosity." Powder Technology 419 (2023): 118334.
  • Kensaku Matsunami, Tomohiro Miura, Keita Yaginuma, Shuichi Tanabe, Sara Badr, Hirokazu Sugiyama. "Surrogate modeling of dissolution behavior toward efficient design of tablet manufacturing processes." Computers & Chemical Engineering 171 (2023): 108141.
  • Kensaku Matsunami, Alexander Ryckaert, Michiel Peeters, Sara Badr, Hirokazu Sugiyama, Ingmar Nopens, Thomas De Beer. "Analysis of the effects of process parameters on start-up operation in continuous wet granulation." Processes 9.9 (2021): 1502.
  • Junu Kim*, Kensaku Matsunami*, Kozue Okamura*, Sara Badr, Hirokazu Sugiyama. (*shared first authorship) "Determination of critical decision points for COVID-19 measures in Japan." Scientific Reports 11.1 (2021): 16416.
  • Kensaku Matsunami, Fabian Sternal, Keita Yaginuma, Shuichi Tanabe, Hiroshi Nakagawa, Hirokazu Sugiyama. "Superstructure-based process synthesis and economic assessment under uncertainty for solid drug product manufacturing." BMC Chemical Engineering 2 (2020): 1-16.
  • Kensaku Matsunami, Takuya Nagato, Koji Hasegawa, Hirokazu Sugiyama. "Determining key parameters of continuous wet granulation for tablet quality and productivity: A case in ethenzamide." International Journal of Pharmaceutics 579 (2020): 119160.
  • Kensaku Matsunami, Takuya Nagato, Koji Hasegawa, Hirokazu Sugiyama. "A large-scale experimental comparison of batch and continuous technologies in pharmaceutical tablet manufacturing using ethenzamide." International journal of pharmaceutics 559 (2019): 210-219.
  • Kensaku Matsunami, Takuya Miyano, Hiroaki Arai, Hiroshi Nakagawa, Masahiko Hirao, Hirokazu Sugiyama. "Decision support method for the choice between batch and continuous technologies in solid drug product manufacturing." Industrial & Engineering Chemistry Research 57.30 (2018): 9798-9809.

Conference presentations

  • (Poster) Kensaku Matsunami*, Alexander Ryckaert, Remco Mariën, Bram Bekaert, Valérie Vanhoorne, Thomas De Beer, Chris Vervaet, Ashish Kumar "Mechanistic and data-driven models for tablet dissolution to identify key parameters in continuous direct compression" 14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 18–21 March 2024, Austria Center Vienna, Vienna, Austria (2024)
  • (Poster) Keita Yaginuma*, Kensaku Matsunami, Laure Descamps, Alexander Ryckaert, Thomas De Beer "Novel approach integrated T-shaped partial least squares regression and transfer learning for tableting scale up" 14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 18–21 March 2024, Austria Center Vienna, Vienna, Austria (2024).
  • (Oral) Kensaku Matsunami*, Ana Alejandra Barrera Jiménez, Thomas De Beer, Ingmar Nopens "Uncertainty analysis of hybrid modeling: A case study of partial least squares and population balance model in continuous twin-screw wet granulation" 2023 AIChE Annual Meeting, 5–10 November 2023, Hyatt Regency, Orlando, USA (2023).
  • (Oral) Kensaku Matsunami*, Remco Mariën, Valérie Vanhoorne, Thomas De Beer, Chris Vervaet, Ashish Kumar "Model-based comparison of dissolution behavior between batch and continuous direct compression manufacturing platforms" 2023 AIChE Annual Meeting, 5–10 November 2023, Hyatt Regency, Orlando, USA (2023).
  • (Oral)Kensaku Matsunami*, Ana Alejandra Barrera Jiménez, Michiel Peeters, Michael Ghijs, Daan Van Hauwermeiren, Thomas De Beer, Ingmar Nopens "Two-dimensional population balance model for twin-screw wet granulation: Model development and calibration based on particle size distribution and porosity" 2022 AIChE Annual Meeting, 13–18 November 2022, Phoenix, AZ, USA (2022).
  • (Oral) Kensaku Matsunami*, Ana Alejandra Barrera Jiménez, Michiel Peeters, Daan Van Hauwermeiren, Thomas De Beer, Ingmar Nopens "In-depth analysis of the impacts of material properties on size distributions in continuous twin-screw wet granulation to construct a generic 1D population balance model" 2022 AIChE Annual Meeting, 13–18 November 2022, Phoenix, AZ, USA (2022).
  • (Poster) Kensaku Matsunami*, Sara Badr, Hirokazu Sugiyama "Framework for designing solid drug product manufacturing processes based on economic and quality assessment" The 14th International Symposium on Process Systems Engineering (PSE 2021+), 19–23 June 2022, Kyoto University Clock Tower Centennial Hall, Kyoto, Japan (2022).
  • (Oral) Ana Alejandra Barrera Jiménez*, Daan Van Hauwermeiren, Kensaku Matsunami, Michiel Peeters, Thomas De Beer, Ingmar Nopens "Towards a generic population balance model for twin-screw wet granulation: from material properties to particle size distribution" 7th International Conference on Population Balance Modelling (PBM 2022), 9–11 May 2022, Lyon, France (2022).
  • (Oral) Kensaku Matsunami*, Tomohiro Miura, Keita Yaginuma, Shuichi Tanabe, Hirokazu Sugiyama "Surrogate modeling of dissolution behavior toward efficient design of tablet manufacturing processes" 2020 AIChE Annual Meeting, 16–20 November 2020, Virtual meeting (2020).
  • (Oral) Kensaku Matsunami*, Fabian Sternal, Keita Yaginuma, Shuichi Tanabe, Hiroshi Nakagawa, Hirokazu Sugiyama "Economic evaluation tool for holistic design of solid drug product manufacturing processes considering continuous technology" 019 AIChE Annual Meeting, 10–15 November 2019, Hyatt Regency, Orlando, U.S.A. (2019).
  • (Oral) Kensaku Matsunami*, Hirokazu Sugiyama "Holistic and model-based design of oral drug manufacturing processes considering uncertainty in clinical development"The 8th International Symposium on Design, Operation, and Control of Chemical Processes (PSE Asia 2019), 13–16 January 2019, Chulalongkorn University, Bangkok, Thailand (2019).
  • (Oral) Kensaku Matsunami*, Shuichi Tanabe, Hiroshi Nakagawa, Masahiko Hirao, Hirokazu Sugiyama "Economic evaluation of batch and continuous manufacturing technologies for solid drug products during clinical development"13th International Symposium on Process Systems Engineering (PSE 2018), 1–5 July 2018, Manchester Grand Hyatt, San Diego, U.S.A. (2018).
  • (Poster) Kensaku Matsunami*, Takuya Nagato, Koji Hasegawa, Masahiko Hirao, Hirokazu Sugiyama "Industrial scale experiments towards the development of process evaluation models for continuous pharmaceutical tablet manufacturing" 28th European Symposium on Computer-Aided Process Engineering (ESCAPE-28), 10–13 June 2018, the Congress Graz, Graz, Austria (2018).
  • (Oral) Kensaku Matsunami*, Takuya Nagato, Koji Hasegawa, Masahiko Hirao, Hirokazu Sugiyama "Large-scale experimental comparison of batch and continuous technologies for pharmaceutical tablet manufacturing" 2017 AIChE Annual Meeting, 29 October–3 November 2017, Minneapolis Convention Center, Minneapolis, U.S.A. (2017).
  • (Poster) Hirokazu Sugiyama*, Kensaku Matsunami, Keisho Yabut "Process systems engineering approaches for drug product manufacturing: from tablets to injectables" 27th European Symposium on Computer-Aided Process Engineering (ESCAPE-27), 1–5 October 2017, Fira de Barcelona, Barcelona, Spain (2017).
  • (Oral) Kensaku Matsunami*, Takuya Miyano, Hiroaki Arai, Hiroshi Nakagawa, Masahiko Hirao, Hirokazu Sugiyama "Selection support methodology between batch and continuous technologies for pharmaceutical tablet manufacturing processes" 2016 AIChE Annual Meeting, 13–18 November 2016, Hilton San Francisco Union Square, San Francisco, U.S.A. (2016).
  • (Oral) Kensaku Matsunami*, Takuya Miyano, Hiroaki Arai, Hiroshi Nakagawa, Masahiko Hirao, Hirokazu Sugiyama "Design method for pharmaceutical tablet production considering batch & continuous technologies" The 7th International Symposium on Design, Operation & Control of Chemical Processes (PSE Asia 2016), 24–27 July 2016, The University of Tokyo, Tokyo, Japan (2016).

Education